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Article

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.

Cell - 31 Jan 2013

Li Qiyuan, Seo Ji-Heui, Stranger Barbara, McKenna Aaron, Pe'er Itsik, Laframboise Thomas, Brown Myles, Tyekucheva Svitlana, Freedman Matthew L

Abstract excerpt

Germline determinants of gene expression in tumors are infrequently studied due to the complexity of transcript regulation caused by somatically acquired alterations. We performed expression quantitative trait locus (eQTL)-based analyses using the multi-level information provided in The Cancer Genome Atlas (TCGA). Of the factors we measured, cis-acting eQTLs accounted for 1.2% of the total variation of tumor gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23374354
DOI: 10.1016/j.cell.2012.12.034
PMCID: PMC4165609

Genes

ESR1
KLF4
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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