Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline Variants That Affect Tumor Progression.

Trends in genetics : TIG - 1 May 2021

Chatrath Ajay, Ratan Aakrosh, Dutta Anindya

Abstract excerpt

Germline variants have a rich history of being studied in the context of cancer risk. Emerging studies now suggest that germline variants contribute not only to cancer risk but to tumor progression as well. In this opinion article, we discuss the initial discoveries associating germline variants with patient outcome and the mechanisms by which germline variants affect molecular pathways. Germline variants affect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Tumor Suppressor
Share to Genetic Predisposition to Disease
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Pharmacogenomic Variants

Share to Polymorphism, Single Nucleotide

Share to Precision Medicine

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 33203571
DOI: 10.1016/j.tig.2020.10.005
PMCID: PMC8043969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline Variants That Affect Tumor Progression.PMID 33203571Read ↗

Germline Variants Impact Somatic Events during TumorigenesisSemantic proximity Read ↗

The pan-cancer landscape of prognostic germline variants in 10,582 patients.Semantic proximity Read ↗

The Pan-Cancer Landscape of Prognostic Germline Variants in 10,582 PatientsSemantic proximity Read ↗

Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories.Semantic proximity Read ↗

Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burdenSemantic proximity Read ↗

Genetic variation across and within individuals.Semantic proximity Read ↗

Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma.Semantic proximity Read ↗

Translating Germline Cancer Risk into Precision Prevention.Semantic proximity Read ↗

The context-specific role of germline pathogenicity in tumorigenesis.Semantic proximity Read ↗

Cancer-predisposing germline variants and subsequent cancer risk.Semantic proximity Read ↗

Pathogenic Germline Variants in 10,389 Adult Cancers.Semantic proximity Read ↗

Distinct mutational landscapes when comparing germline and somatic cancer variants in forty tumor suppressor genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.