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Article

Significance of Cyclooxgenase-2 gene polymorphism and related miRNAs in pulmonary arterial hypertension.

Clinical biochemistry - 1 Sept 2022

Durmus Sinem, Atahan Ersan, Avci Kilickiran Burcak, Onal Burak, Cakatay Ufuk, Gelisgen Remise, Uzun Hafize

Abstract excerpt

BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease with a poor prognosis. The suppression of cyclooxygenase-2 (COX-2) expression has been known to impair vascular function in endothelial cells; however, the epigenetic factors that cause this are largely obscure. Our aim in this study was to examine the polymorphisms in the gene for COX-2 (PTGS2) and related miRNAs regulating its level in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35724768
DOI: 10.1016/j.clinbiochem.2022.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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