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Article

Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension.

JAMA cardiology - 1 Jun 2020

Wang Xiao-Jian, Xu Xi-Qi, Sun Kai, Liu Ke-Qiang, Li Su-Qi, Jiang Xin, Zhao Qin-Hua, Wang Lan, Peng Fu-Hua, Ye Jue, Wu Yan, Jiang Rui, Zhang Jin, Huang Wei, Wei Wen-Bin, Yan Yi, Li Jing-Hui, Liu Qian-Qian, Li Sheng, Wang Yong, Zhang Shu-Yang, Zhang Xue, Jing Zhi-Cheng

Abstract excerpt

Importance: Idiopathic pulmonary arterial hypertension (IPAH) is a fatal disease with high heritability; however, the bone morphogenetic protein receptor 2 (BMPR2) gene only accounts for 17% of IPAH. The genetic basis of IPAH needs further investigation. Objective: To identify novel IPAH susceptibility genes other than BMPR2. Design, Setting, and Participants: This 2-stage, case-control genetic association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32236489
DOI: 10.1001/jamacardio.2020.0479
PMCID: PMC7113838

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