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Article

Gene variants and haplotypes modifying transcription factor binding sites in the human cyclooxygenase 1 and 2 (PTGS1 and PTGS2) genes.

Current drug metabolism - 1 Feb 2014

Agundez Jose A G, Gonzalez-Alvarez David L, Vega-Rodriguez Miguel A, Botello Emilia, Garcia-Martin Elena

Abstract excerpt

Cyclooxygenases (prostaglandin-endoperoxide synthases, (EC 1.14.99.1) 1 and 2 (COX-1 and COX-2)) are key enzymes with a highly functional and pharmacological relevance. Genetic variations in the corresponding genes PTGS1 and PTGS2 are related to diverse human disorders and adverse drug reactions. Although COX-2 is highly inducible, most genetic association studies have focused on coding region gene variants. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24694232
DOI: 10.2174/138920021502140327180336

Genes

PTGS1
PTGS2
CDX1
MYB
SRY

Variants

rs689466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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