Regulation of COX-2 expression by miR-146a in lung cancer cells

Abstract excerpt

Prostaglandins are a class of molecules that mediate cellular inflammatory responses and control cell growth. The oxidative conversion of arachidonic acid to prostaglandin H2 is carried out by two isozymes of cyclooxygenase, COX-1 and COX-2. COX-1 is constitutively expressed, while COX-2 can be transiently induced by external stimuli, such as pro-inflammatory cytokines. Interestingly, COX-2 is overexpressed in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammatory mediators and NSAID effects
• Share to NF-κB Signaling Pathways