Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.

doi:10.2147/COPD.S74345

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Article

Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.

International journal of chronic obstructive pulmonary disease - 1 Jan 2015

Wang Ran, Li Min, Zhou Sijing, Zeng Daxiong, Xu Xuan, Xu Rui, Sun Gengyun

Abstract excerpt

OBJECTIVE: To evaluate the effect of a single nucleotide polymorphism (rs2910164) in the miR-146a precursor on the expression level of miR-146a, cyclooxygenase-2 (COX2), and production of prostaglandin E2 (PGE2) in lung tissue harvested from smokers with chronic obstructive pulmonary disease, as well as the lung function and disease stages from the same patient population. METHODS AND RESULTS: One-hundred and...

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PMID: 25767384
DOI: 10.2147/COPD.S74345
PMCID: PMC4354402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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