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Article

Pharmacogenomics of cyclooxygenases.

Pharmacogenomics - 1 Jan 2015

Agúndez José A G, Blanca Miguel, Cornejo-García José A, García-Martín Elena

Abstract excerpt

Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The genes coding for these enzymes (PTGS1 and PTGS2) are highly variable, and variations in these genes may underlie the risk of developing, or the clinical evolution of, several diseases and adverse drug reactions. We analyze major variations in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25916522
DOI: 10.2217/pgs.15.6

Genes

PTGS1
PTGS2

Provenance

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