Article
Race, Genotype, and Azathioprine Discontinuation : A Cohort Study.
Annals of internal medicine - 1 Aug 2022
Dickson Alyson L, Daniel Laura L, Jackson Elise, Zanussi Jacy, Yang Wenjian, Plummer W Dale, Dupont William D, Wei Wei-Qi, Nepal Puran, Hung Adriana M, Cox Nancy J, Van Driest Sara L, Feng QiPing, Yang Jun J, Stein C Michael, Mosley Jonathan D, Chung Cecilia P
Abstract excerpt
BACKGROUND: Thiopurines are an important class of immunosuppressants despite their risk for hematopoietic toxicity and narrow therapeutic indices. Benign neutropenia related to an ACKR1 variant (rs2814778-CC) is common among persons of African ancestries. OBJECTIVE: To test whether rs2814778-CC was associated with azathioprine discontinuation attributed to hematopoietic toxicity and lower thiopurine dosing....
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