Article
PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine.
Clinical and translational science - 1 Jun 2025
Daniel Laura L, Nepal Puran, Zanussi Jacy, Dickson Alyson L, Straub Peter, Miller-Fleming Tyne W, Wei Wei-Qi, Hung Adriana M, Cox Nancy J, Kawai Vivian K, Mosley Jonathan D, Stein Charles Michael, Feng QiPing, Liu Ge, Tao Ran, Chung Cecilia P
Abstract excerpt
Leukopenia is a common dose-dependent side effect of azathioprine, often leading to drug discontinuation. Variants in TPMT and NUDT15 are associated with azathioprine-induced leukopenia but only explain 25% of cases. Thus, we aimed to identify novel genetic risk factors among TPMT and NUDT15 normal metabolizers through a genome-wide association study (GWAS). Using BioVU, Vanderbilt's electronic health record...
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