Article
Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation.
Pharmacogenetics and genomics - 1 Jan 2018
Leger Paul, Chirwa Sanika, Nwogu Jacinta N, Turner Megan, Richardson Danielle M, Baker Paxton, Leonard Michael, Erdem Husamettin, Olson Lana, Haas David W
Abstract excerpt
BACKGROUND: Atazanavir causes plasma indirect bilirubin to increase. We evaluated associations between Gilbert's polymorphism and bilirubin-related atazanavir discontinuation stratified by race/ethnicity. PATIENTS AND METHODS: Patients had initiated atazanavir/ritonavir-containing regimens at an HIV primary care clinic in the southeastern USA, and had at least 12 months of follow-up data. Metabolizer group was...
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