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Article

Association of TPMT and NUDT15 gene polymorphisms with azathioprine-induced leukopenia: A case-control study in Eastern India.

Indian journal of pharmacology - 1 May 2024

Mitra Sneha, Ghosh Abhijnan, Chatterjee Suparna, Chatterjee Mitali, Sinhamahapatra Pradyot

Abstract excerpt

BACKGROUND: Azathioprine (AZA) is a widely used immunosuppressant drug. Leukopenia is a serious adverse effect of the drug which often necessitates dose reduction or drug withdrawal. Predictors of leukopenia include genetic and nongenetic factors. Genetic polymorphism of AZA-metabolizing enzyme, thiopurine S-methyltransferase (TPMT) is well established. There is inconclusive evidence about the role of Nudix...

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Identifiers

PMID: 39078179
DOI: 10.4103/ijp.ijp_764_23
PMCID: PMC11286099

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