Article
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.
Pharmacogenomics - 1 Jun 2011
Newman William G, Payne Katherine, Tricker Karen, Roberts Stephen A, Fargher Emily, Pushpakom Sudeep, Alder Jane E, Sidgwick Gary P, Payne Debbie, Elliott Rachel A, Heise Marco, Elles Robert, Ramsden Simon C, Andrews Julie, Houston J Brian, Qasim Faeiza, Shaffer Jon, Griffiths Christopher E M, Ray David W, Bruce Ian, Ollier William E R
Abstract excerpt
AIM: To conduct a pragmatic, randomized controlled trial to assess whether thiopurine methyltransferase (TPMT) genotyping prior to azathioprine reduces adverse drug reactions (ADRs). METHODS: A total of 333 participants were randomized 1:1 to undergo TPMT genotyping prior to azathioprine or to commence treatment without genotyping. RESULTS: There was no difference in the primary outcome of stopping azathioprine...
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