Article
Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype.
Alimentary pharmacology & therapeutics - 1 Nov 2017
Broekman M M T J, Coenen M J H, Wanten G J, van Marrewijk C J, Klungel O H, Verbeek A L M, Hooymans P M, Guchelaar H-J, Scheffer H, Derijks L J J, Wong D R, de Jong D J
Abstract excerpt
BACKGROUND: Leucopenia is a common side effect in patients treated with thiopurines. Variants in the thiopurine S-methyltransferase (TPMT) gene are the best-known risk factor, but only explain up to 25% of leucopenia cases. AIM: To identify the clinical risk factors for thiopurine-induced leucopenia in patients without a common TPMT variant, and explore if these patients are at increased risk for infections....
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