Article
Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis.
EBioMedicine - 1 Jul 2015
Cummins Nathan W, Neuhaus Jacqueline, Chu Haitao, Neaton James, Wyen Christoph, Rockstroh Jürgen K, Skiest Daniel J, Boyd Mark A, Khoo Saye, Rotger Margalida, Telenti Amalio, Weinshilboum Richard, Badley Andrew D
Abstract excerpt
BACKGROUND: Efavirenz (EFV) based antiretroviral therapy is expanding worldwide. However discontinuation of EFV containing regimens is common in some patients, particularly black patients, due most often to neuropsychiatric side effects. These adverse drug effects often result in premature drug discontinuation, as well as considerable morbidity. METHODS: We genotyped CYP2A6, CYP2B6 and CYP3A4, which encode...
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