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Article

Clinical Implications of the Duffy-Null Genotype in Patients on Azathioprine or Methotrexate in the All of Us Cohort.

The journal of applied laboratory medicine - 3 Sept 2026

Asiimwe Edgar, Hu Donglei, Cheng Jing, Wu Alan H B, Kushi Lawrence H, Huang Franklin W, Kachuri Linda, Oni-Orisan Akinyemi, Ziv Elad

Abstract excerpt

BACKGROUND: The Duffy null variant (CC genotype) is associated with lower absolute neutrophil count (ANC) and increased risk of early discontinuation or ineligibility for certain treatments. Our primary objective was to evaluate the change in ANC over time among individuals on azathioprine or methotrexate. We also evaluated normality status (i.e., a designation of abnormal vs not) of ANC under genotype-adjusted...

Read the complete abstract on PubMed

Topics

Humans
Methotrexate
Azathioprine
Female
Genotype
Duffy Blood-Group System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Receptors, Cell Surface

Leukocyte Count

Neutrophils

Immunosuppressive Agents

United States

Aged

Cohort Studies

Source

Identifiers

PMID: 42168119
DOI: 10.1093/jalm/jfag056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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Clinical Implications of the Duffy-Null Genotype in Patients on Azathioprine or Methotrexate in the All of Us Cohort.PMID 42168119Read ↗

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