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Article

Azathioprine-related myelosuppression in a patient homozygous for TPMT*3A.

Nature reviews. Nephrology - 28 Jun 2011

Budhiraja Pooja, Popovtzer Mordecai

Abstract excerpt

BACKGROUND: A 50-year-old man who had received a simultaneous pancreas and kidney transplant 9 years earlier developed pancytopenia 3 weeks after starting azathioprine therapy to treat worsening proteinuria suspected to be caused by sirolimus. INVESTIGATIONS: Laboratory tests, including complete blood counts, measurement of serum levels of vitamin B(12) and folate, liver function tests, virological assays, and...

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Source

Identifiers

PMID: 21712851
DOI: 10.1038/nrneph.2011.74

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Azathioprine-related myelosuppression in a patient homozygous for TPMT*3A.PMID 21712851Read ↗

Severe azathioprine-induced myelotoxicity in a kidney transplant patient with thiopurine S-methyltransferase-deficient genotype (TPMT*3A/*3C).Semantic proximity Read ↗

Azathioprine-induced fatal myelosuppression in systemic lupus erythematosus patient carrying TPMT*3C polymorphism.Semantic proximity Read ↗

The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.Semantic proximity Read ↗

Azathioprine-induced fatal myelosuppression in a renal-transplant recipient who carried heterozygous TPMT*1/*3C.Semantic proximity Read ↗

Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.Semantic proximity Read ↗

Impact of the heterozygous TPMT*1/*3C genotype on azathioprine-induced myelosuppression in kidney transplant recipients in Thailand.Semantic proximity Read ↗

[Azathioprine-associated severe myelosuppression: indication of routine determination of thiopurine S-methyltransferase variant?].Semantic proximity Read ↗

Characterization of a novel TPMT mutation associated with azathioprine-induced myelosuppression.Semantic proximity Read ↗

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.Semantic proximity Read ↗

Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms.Semantic proximity Read ↗

Pancytopenia Related to Azathioprine — An Enzyme Deficiency Caused by a Common Genetic Polymorphism: A ReviewSemantic proximity Read ↗

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