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Article

Phasing analysis of lung cancer genomes using a long read sequencer.

Nature communications - 16 Jun 2022

Sakamoto Yoshitaka, Miyake Shuhei, Oka Miho, Kanai Akinori, Kawai Yosuke, Nagasawa Satoi, Shiraishi Yuichi, Tokunaga Katsushi, Kohno Takashi, Seki Masahide, Suzuki Yutaka, Suzuki Ayako

Abstract excerpt

Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct the phasing analysis of non-small cell lung cancer specimens of 20 Japanese patients. By the combinatory use of short and long read sequencing data, we obtain long phased blocks of 834 kb in N50 length with >99% concordance rate. By analyzing the obtained phasing information, we reveal that several cancer genomes harbor regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35710642
DOI: 10.1038/s41467-022-31133-6
PMCID: PMC9203510

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