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HICANCER: accurate and complete cancer genome phasing with Hi-C reads.

Scientific reports - 23 Mar 2021

Pan Weihua, Gong Desheng, Sun Da, Luo Haohui

Abstract excerpt

Due to the high complexity of cancer genome, it is too difficult to generate complete cancer genome map which contains the sequence of every DNA molecule until now. Nevertheless, phasing each chromosome in cancer genome into two haplotypes according to germline mutations provides a suboptimal solution to understand cancer genome. However, phasing cancer genome is also a challenging problem, due to the limit in...

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PMID: 33758310
DOI: 10.1038/s41598-021-86104-6
PMCID: PMC7987978

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