Article

Long read sequencing reveals a novel class of structural aberrations in cancers: identification and characterization of cancerous local amplifications

2019-04-29

Abstract excerpt

Here we report identification of a new class of local structural aberrations in lung cancers. The whole-genome sequencing of cell lines using a long read sequencer, PromethION, demonstrated that typical cancerous mutations, such as point mutations, large deletions and gene fusions can be detected also on this platform. Unexpectedly, we revealed unique structural aberrations consisting of complex combinations of lo...

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Literature Corpus work: 63cb28d6-fbb8-5ab0-8994-0bfc8e82492c
DOI: 10.1101/620047

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