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Article

miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.

Blood - 2 Apr 2015

Hu Wenhuo, Dooley James, Chung Stephen S, Chandramohan Dhruva, Cimmino Luisa, Mukherjee Siddhartha, Mason Christopher E, de Strooper Bart, Liston Adrian, Park Christopher Y

Abstract excerpt

Hematopoietic stem cells (HSCs) possess the ability to generate all hematopoietic cell types and to self-renew over long periods, but the mechanisms that regulate their unique properties are incompletely understood. Herein, we show that homozygous deletion of the miR-29a/b-1 bicistron results in decreased numbers of hematopoietic stem and progenitor cells (HSPCs), decreased HSC self-renewal, and increased HSC...

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Share to Cell Cycle
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25634742
DOI: 10.1182/blood-2014-06-585273
PMCID: PMC4383797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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