Article
GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.
Blood advances - 11 Dec 2018
Jung Moonjung, Cordes Stefan, Zou Jizhong, Yu Shiqin J, Guitart Xavi, Hong So Gun, Dang Vinh, Kang Elaine, Donaires Flavia S, Hassan Sergio A, Albitar Maher, Hsu Amy P, Holland Steven M, Hickstein Dennis D, Townsley Danielle, Dunbar Cynthia E, Winkler Thomas
Abstract excerpt
GATA2 deficiency is an inherited or sporadic genetic disorder characterized by distinct cellular deficiency, bone marrow failure, various infections, lymphedema, pulmonary alveolar proteinosis, and predisposition to myeloid malignancies resulting from heterozygous loss-of-function mutations in the GATA2 gene. How heterozygous GATA2 mutations affect human hematopoietic development or cause characteristic cellular...
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