Article
Hematopoietic defects and iPSC disease modeling: lessons learned.
Immunology letters - 1 Jan 2000
Kelley James M, Daley George Q
Abstract excerpt
Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis....
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