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Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines

13 Aug 2013

Abstract excerpt

Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed 3 separate iPSC clones from fibroblasts of 3 different normal individuals using a standardized approach that included excision...

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PMID: 23940280
DOI: 10.1182/blood-2013-02-484444

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