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Article

Enhanced Extracellular Transfer of HLA-DQ Activates CD3+ Lymphocytes towards Compromised Treg Induction in Celiac Disease.

International journal of molecular sciences - 29 May 2022

Hudec Michael, Juříčková Iva, Riegerová Kamila, Ovsepian Saak V, Černá Marie, O'Leary Valerie Bríd

Abstract excerpt

Celiac disease (CeD) manifests with autoimmune intestinal inflammation from gluten and genetic predisposition linked to human leukocyte antigen class-II (HLA-II) gene variants. Antigen-presenting cells facilitate gluten exposition through the interaction of their surface major histocompatibility complex (MHC) with the T cell receptor (TCR) on T lymphocytes. This fundamental mechanism of adaptive immunity has...

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Identifiers

PMID: 35682780
DOI: 10.3390/ijms23116102
PMCID: PMC9181181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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