Article
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2021
Christophersen Asbjørn, Zühlke Stephanie, Lund Eivind G, Snir Omri, Dahal-Koirala Shiva, Risnes Louise Fremgaard, Jahnsen Jørgen, Lundin Knut E A, Sollid Ludvig M
Abstract excerpt
Gluten-specific CD4+ T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T-cell-directed therapy can change with time and upon activation in CeD and other autoimmune conditions. In-depth characterization of gluten-specific CD4+ T cells and CeD-associated (CD38+ and CD103+ ) CD8+ and γδ+ T cells in blood of treated CeD patients...
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