Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

7 May 2019

Abstract excerpt

Celiac disease (CD) is an immune-mediated disorder triggered by gluten exposure. The contribution of the adaptive immune response to CD pathogenesis has been extensively studied, but the absence of valid experimental models has hampered our understanding of the early steps leading to loss of gluten tolerance. Using intestinal organoids developed from duodenal biopsies from both non-celiac (NC) and celiac (CD)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Celiac Disease Research and Management
Share to Helicobacter pylori-related gastroenterology studies
Share to Microbial Metabolites in Food Biotechnology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31065051
DOI: 10.1038/s41598-019-43426-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac diseasePMID 31065051Read ↗

In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options.Semantic proximity Read ↗

Genome-wide transcriptomic analysis of intestinal mucosa in celiac disease patients on a gluten-free diet and post gluten challengeSemantic proximity Read ↗

Ileal derived organoids from Crohn’s disease patients show unique transcriptomic and secretomic signaturesSemantic proximity Read ↗

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment.Semantic proximity Read ↗

Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease.Semantic proximity Read ↗

Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten ChallengeSemantic proximity Read ↗

T cell mediated impairment of epithelial integrity in Crohn’s diseaseSemantic proximity Read ↗

Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic SignaturesSemantic proximity Read ↗

Diagnosis of celiac disease on a gluten-free diet: a multicenter prospective quasi-experimental clinical studySemantic proximity Read ↗

Novel Bacteroides Vulgatus strain protects against gluten-induced break of human celiac gut epithelial homeostasis: a pre-clinical proof-of-concept studySemantic proximity Read ↗

Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports DiagnosisSemantic proximity Read ↗

A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.