Article
Phenotype-Based Isolation of Antigen-Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2022
Christophersen Asbjørn, Dahal-Koirala Shiva, Chlubnová Markéta, Jahnsen Jørgen, Lundin Knut E A, Sollid Ludvig M
Abstract excerpt
The pathogenic immune response in celiac disease (CeD) is orchestrated by phenotypically distinct CD4+ T cells that recognize gluten epitopes in the context of disease-associated HLA-DQ allotypes. Cells with the same distinct phenotype, but with elusive specificities, are increased across multiple autoimmune conditions. Here, whether sorting of T cells based on their distinct phenotype (Tphe cells) yields...
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