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Article

In Silico Analysis of Functional Overlap and Complementarity of HLA-DQ5 and DQ9 in Gliadin Presentation: Expanding the Immunopeptidomic Landscape of Celiac Disease.

HLA - 1 Jul 2026

Milano Antonio, Crocchiolo Roberto, Anzaldi Noemi, Calligaro Andrea, Gangi Lorenzo, Riva Mariarosa, Scollo Chiara Mariadele

Abstract excerpt

Celiac disease (CD) is classically associated with the HLA-DQ2.5 and HLA-DQ8 heterodimers; however, a clinically relevant subset of patients fulfilling diagnostic criteria lacks these canonical risk HLA-DQ molecules, indicating the presence of alternative antigen-presentation pathways. Among potential contributors, HLA-DQ5 and HLA-DQ9 remain poorly characterised at the immunopeptidomic level. In this study, we...

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Identifiers

PMID: 42362112
DOI: 10.1111/tan.70820
PMCID: PMC13420987

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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