Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-Environment Interactions in Celiac Disease: The Role of the Intestinal Epithelium.

Lifestyle genomics - 1 Jan 2026

Rahmani Sara, Mas-Orea Xavier, Chirdo Fernando G, Verdu Elena F

Abstract excerpt

BACKGROUND: Celiac disease (CeD) is a chronic, immune-mediated condition driven by dietary gluten in genetically predisposed individuals, primarily those carrying HLA-DQ2 and HLA-DQ8. Unlike other autoimmune diseases, CeD offers an exceptional degree of mechanistic clarity, stemming from the identification of the main environmental driver, gluten, and its link with genetic susceptibility. SUMMARY: While gluten...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Celiac Disease
Share to Gastrointestinal Microbiome
Share to Glutens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to HLA-DQ Antigens

Share to Intestinal Mucosa

Share to Protein Glutamine gamma Glutamyltransferase 2

Share to Transglutaminases

Source

Open in PubMed Open full text

Identifiers

PMID: 41980007
DOI: 10.1159/000551888
PMCID: PMC13290135

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-Environment Interactions in Celiac Disease: The Role of the Intestinal Epithelium.PMID 41980007Read ↗

An updated overview on celiac disease: from immuno-pathogenesis and immuno-genetics to therapeutic implications.Semantic proximity Read ↗

Co-factors, Microbes, and Immunogenetics in Celiac Disease to Guide Novel Approaches for Diagnosis and Treatment.Semantic proximity Read ↗

Pathophysiology and immunogenetics of celiac disease.Semantic proximity Read ↗

Non-Host Factors Influencing Onset and Severity of Celiac Disease.Semantic proximity Read ↗

Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac diseaseSemantic proximity Read ↗

Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature.Semantic proximity Read ↗

The Role of Intestinal Microbiota in Celiac Disease and Further Therapeutic PerspectivesSemantic proximity Read ↗

Frontiers in Celiac Disease: Where Autoimmunity and Environment Meet.Semantic proximity Read ↗

Celiac Disease: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Strategies.Semantic proximity Read ↗

Pathophysiology of celiac disease.Semantic proximity Read ↗

Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac DiseaseSemantic proximity Read ↗

New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.