Article
Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer.
Cancer cell - 14 Sept 2026
Manca Paolo, Walch Henry, Xu Jierui, Small Natalie, Kris Ayush, Seffar Evan, Richards Allison, Xue Tiffany, Price Adam, Donoghue Mark T A, Fong Christopher, Waters Michele, Jee Justin, Deshmukh Sachin Kumar, Sledge George W, Malla Midhun, Cercek Andrea, Saltz Leonard, Segal Neil H, Stadler Zsofia K, Nusrat Maliha, Foote Michael B, Desai Avni, Chalasani Sree, Rao Devika, Connell Louise, Do Richard K G, Ganesh Karuna, Weiser Martin R, Berger Michael F, Solit David B, Shia Jinru, Vakiani Efsevia, Garcia-Aguilar Julio, Schultz Nikolaus, Sanchez-Vega Francisco, Chatila Walid K, Yaeger Rona
Abstract excerpt
We performed an integrated clinical and genomic analysis of over 7,000 consecutively sequenced colorectal cancer (CRC) samples to comprehensively characterize genetic drivers and metastatic tropisms of CRC. We find that genomic evolutionary changes, such as clonal mutations and oncogenic mutant allelic imbalance, selectively enhance the impact of recurrent oncogenic alterations. We identify the relative timing of...
Read the complete abstract on PubMedTopics
- Humans
- Colorectal Neoplasms