Article
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.
Signal transduction and targeted therapy - 23 Sept 2024
Cai Jianqiang, Zhang Weilong, Lu Yalan, Liu Wenjie, Zhou Haitao, Liu Mei, Bi Xinyu, Liu Jianmei, Chen Jinghua, Yin Yanjiang, Deng Yiqiao, Luo Zhiwen, Yang Yi, Chen Qichen, Chen Xiao, Xu Zheng, Zhang Yueyang, Wu Chaoling, Long Qizhao, Huang Chunyuan, Yan Changjian, Liu Yan, Guo Lei, Li Weihua, Yuan Pei, Jiao Yucheng, Song Wei, Wang Xiaobing, Huang Zhen, Ying Jianming, Zhao Hong
Abstract excerpt
Liver metastasis remains the primary cause of mortality in patients with colon cancer. Identifying specific driver gene mutations that contribute to metastasis may offer viable therapeutic targets. To explore clonal evolution and genetic heterogeneity within the metastasis, we conducted single-cell exome sequencing on 150 single cells isolated from the primary tumor, liver metastasis, and lymphatic metastasis...
Topics
- Humans
- Colonic Neoplasms
- Repressor Proteins
- Liver Neoplasms
- Single-Cell Analysis
- Exome Sequencing
- Mutation
- Lymphatic Metastasis