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Research progress on genetic heterogeneity between primary and paired metastatic colorectal cancer.

Yi chuan = Hereditas - 20 Jun 2017

Lu You-Wang, Wang Kun-Hua

Abstract excerpt

Colorectal cancer (CRC) is one of the leading causes of cancer deaths in China. A standard practice in treating metastatic CRC (mCRC) is to predict benefits of the anti-EGFR monoclonal antibody treatment based on the somatic mutation spectrum. Because metastatic samples are difficult to obtain clinically, primary tumors are normally used instead. However, due to the genetic heterogeneity between primary and...

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PMID: 28903907
DOI: 10.16288/j.yczz.16-357

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EGFR

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