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Article

Comprehensive Mutation Profiling of Colorectal Cancer Patients With Lung or Liver Metastasis by Targeted Next-Generation Sequencing.

Technology in cancer research & treatment - 1 Jan 2000

Hu Chun-Ting, Wang Jing-Long, Hou Ting, Yan Zhao-Wen, Zu Li-Dong, Fu Guo-Hui, Shen Wei-Wei

Abstract excerpt

OBJECTIVES: Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such as liver and lung metastases. METHODS: We performed in-depth targeted next-generation sequencing of 520 key cancer-associated genes for 47 matched primary and...

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PMID: 37394872
DOI: 10.1177/15330338231185285
PMCID: PMC10328164

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