Article
Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae.
Current genetics - 1 Aug 2022
Mora-García Martín, Ascencio Diana, Félix-Pérez Tania, Ulloa-Calzonzin Judith, Juárez-Reyes Alejandro, Robledo-Márquez Karina, Rebolloso-Gómez Yolanda, Riego-Ruiz Lina, DeLuna Alexander, Calera Mónica R, Sánchez-Olea Roberto
Abstract excerpt
The GPN-loop GTPase Npa3 is encoded by an essential gene in the yeast Saccharomyces cerevisiae. Npa3 plays a critical role in the assembly and nuclear accumulation of RNA polymerase II (RNAPII), a function that may explain its essentiality. Genetic interactions describe the extent to which a mutation in a particular gene affects a specific phenotype when co-occurring with an alteration in a second gene....
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