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Article

GTPase Npa3-TORC1 crosstalk suggests genetic coordination of nutrient sensing and translational control.

FEBS letters - 1 Apr 2026

Mora-García Martín, DelaGarza-Varela Alda, Rebolloso-Gómez Yolanda, Félix-Pérez Tania, Peña-Gómez Sonia G, Riego-Ruiz Lina, Sánchez-Olea Roberto, Calera Mónica R

Abstract excerpt

The GPN-loop GTPase Npa3 plays a critical role in RNA polymerase II (RNAPII) assembly and nuclear import. We employed here the npa3ΔC mutant, which supports normal RNAPII localization and function, to investigate potential links between Npa3 and target of rapamycin complex I (TORC1) signaling. The npa3ΔC cells exhibited increased sensitivity to rapamycin, a synthetic sickness interaction with tor1Δ, and a delayed...

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Share to GTP Phosphohydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41542892
DOI: 10.1002/1873-3468.70285

Genes

RGS2
LTV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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GTPase Npa3-TORC1 crosstalk suggests genetic coordination of nutrient sensing and translational control.PMID 41542892Read ↗

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