Article

Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer

2025-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Mutational signature analysis has greatly enhanced our understanding of the mutagenic processes found in cancer and normal tissues. As part of a recent study, we analyzed 802 treatment-naïve, microsatellite-stable colorectal cancers (CRC) and identified a de novo signature, SBS_D, which was conservatively decomposed into SBS18, a signature associated with reactive oxygen species. Here, we re-ev...

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Literature Corpus work: d9c001b1-33af-522d-8cfa-42fbe133a53b
DOI: 10.1101/2025.06.06.658321

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