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Article

Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice.

Genome research - 7 Feb 2024

Ohno Mizuki, Takano Noriko, Hidaka Kyoko, Sasaki Fumiko, Yamauchi Kazumi, Aoki Yasunobu, Nohmi Takehiko, Nakabeppu Yusaku, Nakatsu Yoshimichi, Tsuzuki Teruhisa

Abstract excerpt

Oxidative stress-induced DNA damage and its repair systems are related to cancer etiology; however, the molecular basis triggering tumorigenesis is not well understood. Here, we aimed to explore the causal relationship between oxidative stress, somatic mutations in pre-tumor-initiated normal tissues, and tumor incidence in the small intestines of MUTYH-proficient and MUTYH-deficient mice. MUTYH is a base excision...

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Amino Acids
Carcinogenesis
Cell Transformation, Neoplastic
DNA Repair
Guanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Oxidative Stress

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Identifiers

PMID: 38290979
DOI: 10.1101/gr.278326.123
PMCID: PMC10904009

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