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Article

Recurrent noncoding somatic and germline WT1 variants converge to disrupt MYB binding in acute promyelocytic leukemia.

Blood - 8 Sept 2022

Song Huan, Liu Yabin, Tan Yun, Zhang Yi, Jin Wen, Chen Li, Wu Shishuang, Yan Jinsong, Li Junmin, Chen Zhu, Chen Saijuan, Wang Kankan

Abstract excerpt

Genetic alternations can occur at noncoding regions, but how they contribute to cancer pathogenesis is poorly understood. Here, we established a mutational landscape of cis-regulatory regions (CREs) in acute promyelocytic leukemia (APL) based on whole-genome sequencing analysis of paired tumor and germline samples from 24 patients and epigenetic profiling of 16 patients. Mutations occurring in CREs occur...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Promyelocytic, Acute

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Share to Proto-Oncogene Proteins c-myb

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Source

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Identifiers

PMID: 35653587
DOI: 10.1182/blood.2021014945
PMCID: PMC9461475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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