Article
WT1 mutations in T-ALL.
Blood - 30 Jul 2009
Tosello Valeria, Mansour Marc R, Barnes Kelly, Paganin Maddalena, Sulis Maria Luisa, Jenkinson Sarah, Allen Christopher G, Gale Rosemary E, Linch David C, Palomero Teresa, Real Pedro, Murty Vundavalli, Yao Xiaopan, Richards Susan M, Goldstone Anthony, Rowe Jacob, Basso Giuseppe, Wiernik Peter H, Paietta Elisabeth, Pieters Rob, Horstmann Martin, Meijerink Jules P P, Ferrando Adolfo A
Abstract excerpt
The molecular mechanisms involved in disease progression and relapse in T-cell acute lymphoblastic leukemia (T-ALL) are poorly understood. We used single nucleotide polymorphism array analysis to analyze paired diagnostic and relapsed T-ALL samples to identify recurrent genetic alterations in T-ALL. This analysis showed that diagnosis and relapsed cases have common genetic alterations, but also that relapsed...
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