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Article

Discovery of Cis-Regulatory Mechanisms via Non-Coding Mutations in Acute Lymphoblastic Leukemia.

Genes, chromosomes & cancer - 1 Mar 2025

Aydın Efe, Woodward Eleanor L, Dushime Gladys Telliam, Gunnarsson Rebeqa, Lilljebjörn Henrik, Moura-Castro Larissa H, Fioretos Thoas, Johansson Bertil, Paulsson Kajsa, Yang Minjun

Abstract excerpt

The non-coding genome, constituting 98% of human DNA, remains largely unexplored, yet holds potential for identifying new biomarkers and therapeutic targets in acute lymphoblastic leukemia (ALL). In this study, we conducted a systematic analysis of recurrent somatic non-coding single nucleotide variants (SNVs) in pediatric B-cell precursor (BCP) ALL. We leveraged whole genome sequencing (WGS) data from 345...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40145864
DOI: 10.1002/gcc.70045
PMCID: PMC11949094

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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