Discovery of candidate functional non-coding mutations in acute myeloid leukemia using single-cell chromatin accessibility sequencing.

Abstract excerpt

Mutations and gene rearrangements are crucial for the diagnosis and subtyping of acute myeloid leukemia (AML). However, the contribution of non-coding genetic variants, particularly those within cis-regulatory elements (CREs), to AML pathophysiology and heterogeneity remains poorly understood. In this study, we characterize the single-cell chromatin accessibility landscapes of 10 bone marrow samples from AML...

Topics

• Humans
• Leukemia, Myeloid, Acute
• Mutation
• Single-Cell Analysis
• Chromatin
• Regulatory Sequences, Nucleic Acid