Article
Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia.
Nature communications - 17 Mar 2022
Binder Moritz, Carr Ryan M, Lasho Terra L, Finke Christy M, Mangaonkar Abhishek A, Pin Christopher L, Berger Kurt R, Mazzone Amelia, Potluri Sandeep, Ordog Tamas, Robertson Keith D, Marks David L, Fernandez-Zapico Martin E, Gaspar-Maia Alexandre, Patnaik Mrinal M
Abstract excerpt
Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential acquisition of recurrent genetic lesions. Truncating mutations in the chromatin remodeler ASXL1 (ASXL1MT) are associated with a high-risk disease phenotype with increased proliferation, epigenetic therapeutic resistance, and poor survival outcomes. We performed a multi-omics interrogation to define gene expression and...
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