Article

5’tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes

2025-07-22

Abstract excerpt

<h4>ABSTRACT</h4> During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of transfer RNAs (tRNAs) generates tRNA-derived fragments (tRFs), whose role in this context is not fully understood. We identify elevated levels of 5’tRF Glu(CTC) and 5’tRF...

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Literature Corpus work: d90bc1f9-5000-5b58-a205-c878b7ae7bd6
DOI: 10.1101/2025.07.22.665911

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