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Article

Extensive simulations assess the performance of genome-wide association mapping in various Saccharomyces cerevisiae subpopulations.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 18 Jul 2022

Peter Jackson, Friedrich Anne, Liti Gianni, Schacherer Joseph

Abstract excerpt

With the advent of high throughput sequencing technologies, genome-wide association studies (GWAS) have become a powerful paradigm for dissecting the genetic origins of the observed phenotypic variation. We recently completely sequenced the genome of 1011 Saccharomyces cerevisiae isolates, laying a strong foundation for GWAS. To assess the feasibility and the limits of this approach, we performed extensive...

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PMID: 35634920
DOI: 10.1098/rstb.2020.0514
PMCID: PMC9149792

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