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Article

Extensive impact of low-frequency variants on the phenotypic landscape at population-scale.

eLife - 24 Oct 2019

Fournier Téo, Abou Saada Omar, Hou Jing, Peter Jackson, Caudal Elodie, Schacherer Joseph

Abstract excerpt

Genome-wide association studies (GWAS) allow to dissect complex traits and map genetic variants, which often explain relatively little of the heritability. One potential reason is the preponderance of undetected low-frequency variants. To increase their allele frequency and assess their phenotypic impact in a population, we generated a diallel panel of 3025 yeast hybrids, derived from pairwise crosses between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31647416
DOI: 10.7554/eLife.49258
PMCID: PMC6892612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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