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Article

Strategies for detecting susceptibility genes in a complex disease.

Genetic epidemiology - 1 Jan 1999

Babron M C, Barillot E, Margaritte-Jeannin P, Clerget-Darpoux F

Abstract excerpt

One of the current issues in genetic epidemiology is detecting susceptibility genes on the genome. It is common now to undertake systematic screening of the genome using approaches based on a measure of the haplotype sharing in sib pairs. Here, we compare the efficiency of two statistics, the maximum likelihood score (MLS) and the nonparametric linkage score (NPLa) on the simulated data provided for GAW11. A...

Topics

Genetic Linkage
Genetic Predisposition to Disease
Genetic Testing
Genome
Humans
Likelihood Functions
Lod Score
Models, Genetic
Statistics, Nonparametric

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10597479
DOI: 10.1002/gepi.1370170777

Genes

NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10597479-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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