Article
Mapping small effect mutations in Saccharomyces cerevisiae: impacts of experimental design and mutational properties.
G3 (Bethesda, Md.) - 29 Apr 2014
Duveau Fabien, Metzger Brian P H, Gruber Jonathan D, Mack Katya, Sood Natasha, Brooks Tiffany E, Wittkopp Patricia J
Abstract excerpt
Genetic variants identified by mapping are biased toward large phenotypic effects because of methodologic challenges for detecting genetic variants with small phenotypic effects. Recently, bulk segregant analysis combined with next-generation sequencing (BSA-seq) was shown to be a powerful and cost-effective way to map small effect variants in natural populations. Here, we examine the power of BSA-seq for...
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