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Benchmarking bacterial genome-wide association study methods using simulated genomes and phenotypes.

Microbial genomics - 1 Mar 2020

Saber Morteza M, Shapiro B Jesse

Abstract excerpt

Genome-wide association studies (GWASs) have the potential to reveal the genetics of microbial phenotypes such as antibiotic resistance and virulence. Capitalizing on the growing wealth of bacterial sequence data, microbial GWAS methods aim to identify causal genetic variants while ignoring spurious associations. Bacteria reproduce clonally, leading to strong population structure and genome-wide linkage, making...

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PMID: 32100713
DOI: 10.1099/mgen.0.000337
PMCID: PMC7200059

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