Article
Local ancestry corrects for population structure in Saccharomyces cerevisiae genome-wide association studies.
Genetics - 1 Dec 2012
Diao Liyang, Chen Kevin C
Abstract excerpt
Genome-wide association studies (GWAS) have become an important method for mapping the genetic loci underlying complex phenotypic traits in many species. A crucial issue when performing GWAS is to control for the underlying population structure because not doing so can lead to spurious associations. Population structure is a particularly important issue in nonhuman species since it is often difficult to control...
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